Advantage Healojoint capsules
While the market is flooded with joint care supplements — from glucosamine and collagen type II to rosehip extract, turmeric, and boswellia — most of these are intended for long-term cartilage support. They are not designed to offer rapid relief from pain, inflammation, and edema, which are common during joint flare-ups.Even though these ingredients have value, they typically take 30–45 days to begin showing effect. In contrast, Healojoint is a fast-acting, next-generation formulation created specifically for acute joint pain, inflammatory flares, and post-procedural care. Its unique combination of high-bioavailable and clinically validated ingredients delivers targeted relief, setting it apart from conventional joint supplements.
Healojoint is specially formulated for managing acute joint pain, inflammation, redness, and swelling, offering targeted relief in conditions where quick recovery is critical. It is recommended in:
• Osteoarthritis flare-ups – of the knee, hip, or shoulder, with associated pain, stiffness, and swelling
• Autoimmune or hyperimmune joint conditions – such as rheumatoid arthritis, reactive arthritis, or inflammatory shoulder syndromes
• Injury-induced joint inflammation – including ACL/PCL tears, meniscal injuries, ligament sprains, or joint trauma
• Sports-related overuse injuries – such as patellar tendinopathy, shoulder impingement, rotator cuff strain, and post-training joint swelling
• Post-procedural joint care – following arthroscopy, intra-articular injections (PRP, stem cells), or cartilage repair procedures
• Bridging therapy – while awaiting surgical or regenerative treatment, where inflammation control is essential but NSAIDs/steroids are not preferred.
Healojoint is a trusted NSAID-sparing solution with minimal side effects, designed to complement physiotherapy, orthobiologics, and rehabilitation protocols for faster and safer recovery.
Recommended Dose:
Acute stage : 1 capsule twice daily (5-10 days, followed by 1 capsule for 2-3 months. for 1st 30 days, followed by 1 capsule daily
Curcumin for Osteoarthritis
- Efficacy and Safety of Curcumin Therapy for Knee Osteoarthritis: A Bayesian Network Meta Analysis
Journal of Ethnopharmacology (2024)
Key Findings:
- Included 23 RCTs (2,175 patients) assessing curcumin vs placebo/NSAIDs
- Significantly reduced VAS pain (MD –1.63) and WOMAC (MD –18.85)
- Curcumin alone or with NSAIDs decreased rescue medication use
- Curcumin had fewer adverse reactions than NSAIDs
Conclusion: Shows strong clinical efficacy and safety; effective alone or adjunctively in KOA - To read more:
pmc.ncbi.nlm.nih.gov + pubmed.ncbi.nlm.nih.gov + bmccomplementmedtherapies.biomedcentral.com
- Comparison of Curcuminoid Formulations or Its Combination with Conventional Therapies Versus Conventional Therapies Alone for Knee Osteoarthritis
Clinical Rheumatology (2022)
Key Findings:
- Compared nano-curcumin/water-dispersible forms with/without conventional therapy
- Demonstrated greater pain and function improvement (VAS & WOMAC)
Conclusion: Advanced formulations offer better outcomes than conventional therapies - To read more:
pubmed.ncbi.nlm.nih.gov + tandfonline.com + verywellhealth.com + medsci.org
- Osteoarthritis: Insights into Diagnosis, Pathophysiology, Therapeutic Avenues, and the Potential of Natural Extracts
Journal of Current Research in Molecular Biology (2024)
Key Findings:
- Reviews natural compounds (curcumin, boswellic acids) and their effects on NF-κB, IL-1β, MMPs
- Highlights improved efficacy with micellar/nano delivery systems
Conclusion: Supports use of bioavailable phytochemicals for inflammation and cartilage protection - To read more:
pubmed.ncbi.nlm.nih.gov bmccomplementmedtherapies.biomedcentral.com
- Bioactive Compounds and Their Chondroprotective Effects for Osteoarthritis Amelioration: A Focus on Nanotherapeutic Strategies, Epigenetic Modifications, and Gut Microbiota
Nutrients (2024)
Key Findings:
- Nanocurcumin modulates epigenetic mechanisms and gut microbiota, enhancing chondrocyte function
- Combines anti-inflammatory and structural joint benefits
Conclusion: Nanotechnology in nutraceuticals supports both symptom relief and cartilage health - To read more:
researchgate.net pubmed.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov verywellhealth.com
- Bioactive Compounds in Osteoarthritis: Molecular Mechanisms and Therapeutic Roles
Journal of Molecular Research (2024)
Key Findings:
- Curcumin, boswellic acids, bromelain inhibit COX-2, TNF-α, MMPs
- Support cartilage matrix preservation and reduce synovial inflammation
Conclusion: Validates molecular mechanisms behind joint-protective nutraceuticalsTo read more:
bmccomplementmedtherapies.biomedcentral.com verywellhealth.com researchgate.net medsci.org
- Efficacy of Curcumin and Boswellia for Knee Osteoarthritis: Systematic Review and Meta Analysis
Seminars in Arthritis & Rheumatism (2018)
Key Findings:
- Joint curcumin-boswellia therapy reduced pain and stiffness vs controls
- Comparable to NSAIDs but with fewer gastrointestinal side effects
Conclusion: Strong evidence for combined botanical synergy in OA symptom relief
- Efficacy of Curcuma longa in Relieving Pain Symptoms of Knee Osteoarthritis Patients: A Systematic Review and Meta Analysis (2022)
Key Findings:
- Meta-analysis of multiple clinical trials shows significant pain and function improvements, non-inferior to NSAIDs
Conclusion: Curcuma longa extract is a safe and effective option for knee OA - To read more:
reddit.com synapse.koreamed.org
- Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: Systematic Review and Meta Analysis
Frontiers in Immunology (2022)
Key Findings:
- Analysis of 29 RCTs (2,396 subjects) across OA, RA, gout
- Reduced pain scores (VAS, WOMAC), ESR, CRP, and DAS28 without increasing side effects
Conclusion: Confirms efficacy and safety of curcumin across different arthritis types - To read more:
pmc.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov jrd.or.kr medsci.org synapse.koreamed.org - Boswellia Serrata (AKBA) for Joint SupportEfficacy and Safety of AKBA -Boswellia a Novel Boswellia serrata Extract, in the Treatment of Osteoarthritis of the Knee: 30 Day RCT
- Journal of the American Nutrition Association (2023)
Key Findings:
- 100 mg/day Aflapin® showed 45% VAS reduction, 44% WOMAC improvement within 30 days
- Decreases in MMP 3, TNF α, hsCRP; no adverse events
Conclusion: Fast-acting and safe, with biochemical evidence of anti-inflammatory and cartilage-protective action - To read more:
sciencedirect.com pubmed.ncbi.nlm.nih.gov medsci.org
- Standardized Boswellia serrata Extract Shows Improvements in Knee Osteoarthritis Within Five Days: RCT
Frontiers in Pharmacology (2024)
Key Findings:
- Patients reported significant VAS/WOMAC improvement within 5 days
- Reduced synovial inflammation; sustained benefits over 4 weeks
Conclusion: Rapid onset efficacy supports early symptomatic relief
- Comparative Efficacy and Tolerability of 5 Loxin® and Aflapin® in Knee Osteoarthritis: 90 Day RCT
International Journal of Medical Sciences (2011)
Key Findings:
- Aflapin® reduced VAS (12.8%) and WOMAC scores (11.8–18.5%) by week 1, superior to 5 Loxin
- Inhibition of MMP 3 and ICAM 1 confirmed in vitro; no safety concerns
Conclusion: Demonstrates faster, stronger anti-inflammatory effects over similar extracts - To read more:
medsci.org
- Potential Complementary/Synergistic Effects of Curcumin and Boswellic Acids for Osteoarthritis
Therapeutic Advances in Musculoskeletal Disease (2022)
Key Findings:
- Combination therapy modulated key inflammatory mediators (IL 1β, TNF α) more than monotherapy
- Synergy shown in symptom reduction and cartilage protection
Conclusion: Clinical rationale for combining curcumin + boswellic acids in joint care
- Curcuma longa and Boswellia serrata Extract Combination for Hand Osteoarthritis: Open Label Trial (2024)
Journal of Pharmaceutical Biology
Key Findings:
- 30% improvement in pain and grip strength after 8 weeks
- Reduced analgesic use; high tolerability
Conclusion: Effective botanical combo for hand OA with functional benefits
- Curcuminoids and Boswellia serrata Extracts Combination Decreases Tendinopathy Symptoms
Current Medical Research (2021)
Key Findings:
- 40% pain reduction and functional improvement (VISA scores) in tendon injuries
Conclusion: Suggests broader musculoskeletal benefits beyond joints
- Co Analgesic Therapy in Arthroscopic Supraspinatus Repair Using Boswellia & Curcuma
Musculoskeletal Surgery (2019)
Key Findings:
- Reduced post-operative pain and NSAID requirements in first week
- No increases in GI issues or bleeding
Conclusion: Effective adjunct for surgical recovery
- Bromelain for Pain and Inflammation
- Bioactive Compounds in Osteoarthritis: Molecular Mechanisms and Therapeutic Roles
Journal of Molecular Research (2024)
Key Findings:
- Covers curcumin, boswellic acids, bromelain for inhibiting COX 2, TNF α, MMPs, promoting cartilage health
Conclusion: Reinforces molecular basis for multi-ingredient anti-inflammatory therapy
- Bromelain as a Treatment for Osteoarthritis: A Review of Clinical Studies
Evidence-Based Complementary and Alternative Medicine (2004)
Key Findings:
- Across multiple clinical trials, bromelain doses ranging from 270 mg to 1,890 mg/day demonstrated significant reductions in knee osteoarthritis pain and stiffness, comparable to standard NSAIDs. Patients reported improved joint function and mobility. Adverse effects were minimal, primarily mild GI discomfort, and no serious safety concerns were found.
Conclusion: Bromelain is an effective, well-tolerated natural alternative to NSAIDs for reducing symptoms of OA, with a favorable risk-benefit profile.
- The Effects of Bromelain on Osteoarthritis Symptoms: A Systematic Review
Journal of Shahrekord University of Medical Sciences (2023)
Key Findings:
- Fourteen studies evaluated bromelain’s impact in OA. Consistently, bromelain lowered inflammatory cytokines (TNF-α, IL-6, IL-8, IL-1β) and bradykinin levels, reduced oxidative stress markers, and alleviated edema. Clinical outcome measures demonstrated significant reductions in pain scores, improved joint range of motion, and decreased stiffness. Minor adverse effects were infrequent.
Conclusion: Strong evidence supports bromelain’s anti-inflammatory and analgesic role in OA management, improving patient symptoms without serious side effects. - To read more:
PubMed
- Bromelain Extract Exerts Anti-arthritic Effects via Chondroprotection and the Suppression of TNF Induced NF κB and MAPK Signaling
Plants (2022)
Key Findings:
- In both cell culture and animal models, bromelain significantly reduced TNF-α–induced activation of NF-κB and MAPK pathways—major mediators of inflammation and cartilage degradation. Bromelain-treated cartilage showed reduced expression of degradative enzymes (e.g., MMP-13) and lower inflammatory protein levels. Histological analysis confirmed preserved cartilage structure.
Conclusion: Mechanistic evidence supports bromelain’s ability to protect joint cartilage and reduce inflammation—laying the foundation for its use in clinical osteoarthritis treatment. - To read more:
PubMed
- The Effects of Bromelain on Osteoarthritis Symptoms: A Systematic Review (Repeated entry)
Journal of Shahrekord University of Medical Sciences (2023)
Key Findings:
- This comprehensive analysis of 14 clinical trials confirmed bromelain’s efficacy in reducing pain, improving mobility, and lowering swelling in OA patients. Biomarkers for inflammation and joint function improved consistently across studies. Very few adverse events were reported, reinforcing bromelain’s tolerability.
Conclusion: Bromelain is a safe and effective supplement for managing symptoms of osteoarthritis, demonstrating consistent anti-inflammatory and functional benefits.
PubMed
- Bromelain as a Treatment for Osteoarthritis: A Review of Clinical Studies
Evidence-Based Complementary and Alternative Medicine (2004)
Key Findings:
- Summary of clinical trials using doses between 160 mg–1,000 mg/day showed meaningful pain score reductions, improved joint stiffness, and enhanced physical function. Patients using bromelain experienced fewer GI adverse effects compared to NSAIDs.
Conclusion: Bromelain emerges as a viable NSAID-sparing therapy in OA, with documented symptom improvement and good safety—though additional long-term and larger-scale research is required. - To read more:
PubMed Central (PMC)
vijaya Mehta –
Healojoint worked very well for my hip arthritis; taking for last 4 months and i could delay and slowly forgeting about my hip issue. thanks to my dr who recommended it.
Mukta Srinivas –
various joint pain products earlier available contain animal processed ingredients which i always used to avoid. finding an effective alternative is welcoming. i find healojoint good in relieving my knee pain.