WHY COMBINE IRON WITH LACTOFERRIN?
Lactoferrin is a natural iron-transporting protein that improves intestinal iron uptake and supports efficient delivery of iron to bone marrow for red blood cell formation. It also helps reduce inflammation-related iron trapping, improving hemoglobin correction compared with conventional iron salts.
WHY LIPOSOMAL IRON WORKS BETTER THAN CONVENTIONAL IRON TABLETS
Traditional iron salts release free iron ions in the digestive tract, which often leads to constipation, nausea and poor compliance. Liposomal ferric pyrophosphate protects iron from gastric degradation and enables stable intestinal absorption with fewer gastrointestinal side effects and improved tolerability.
WHY VITAMIN B12 IS INCLUDED IN PRECIFER
Vitamin B12 supports DNA synthesis and red blood cell maturation, ensuring absorbed iron is effectively utilized during hemoglobin production rather than remaining metabolically inactive.
LIPOSOMAL IRON FOR HAIR FALL, FATIGUE AND LOW FERRITIN
Low ferritin levels are associated with fatigue, reduced exercise tolerance and increased hair shedding. Liposomal iron with lactoferrin supports restoration of ferritin stores while maintaining gastrointestinal comfort during supplementation.
HOW PRECIFER COMPARES WITH COMMONLY PRESCRIBED IRON TABLETS IN INDIA
| Feature | Ferrous Ascorbate | Carbonyl Iron | Iron Polymaltose | PRECIFER Liposomal Iron |
| Absorption consistency | Moderate | Variable | Moderate | Higher |
| Constipation risk | Common | Moderate | Lower | Reduced |
| Gastric irritation | Frequent | Moderate | Lower | Minimal |
| Iron transport efficiency | Limited | Limited | Limited | Enhanced with lactoferrin |
| Ferritin restoration support | Moderate | Moderate | Moderate | Improved utilization support |
| Long-term tolerability | Moderate | Moderate | Moderate | Better compliance potential |
ADDITIONAL ADVANTAGES OF PRECIFER LIPOSOMAL IRON
- Supports predictable hemoglobin improvement
- Improves ferritin restoration
- Enhances intestinal iron absorption
- Reduces constipation risk
- Improves tolerance during prolonged supplementation
- Supports red blood cell formation with vitamin B12 synergy
WHO MAY BENEFIT MOST FROM LIPOSOMAL IRON SUPPLEMENTATION?
- Individuals with chronic iron deficiency anemia
- Women with menstrual blood loss
- Vegetarians and low dietary iron intake
- Patients intolerant to conventional iron salts
- Individuals with low ferritin-related hair fall
- Patients recovering from infection or surgery
Latest Scientific Studies on Encapsulated Ferric Pyrophosphate Iron
Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy; Cureus 2024
Key Findings
These findings suggest that Encapsulated Ferric pyrophosphate could be a valuable therapeutic option for managing iron deficiency anemia in pregnant women, promoting better maternal and fetal outcomes. Further research with an increased sample size is warranted to delve into the underlying mechanisms behind these positive outcomes, nonetheless, our study provides a promising foundation for addressing this critical health issue.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11056223/
Effects of micronised microencapsulated ferric pyrophosphate supplementation in patients with advanced cancer and iron deficiency: a single-centre cohort pilot study; Jr of Blood Transfusion 2021
Key Findings
The supplementation of 30 mg/d of micronized Ferric pyrophosphate in combination with 80 mg/d of ascorbic acid in advanced cancer patients with hyposideraemia led to a significant increase in sideraemia and ferritinaemia. Moreover, in some of the patients whose serum iron level did not increase, an increase in haemoglobin was observed.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596375/
Efficacy of a Novel Food Supplement (Ferfer®) Containing Microencap in Liposomal Form in Female Iron Deficiency Anemia ; Cureus 2019
Key Findings
Treatment of IDA with microencapsulated liposomal iron pyrophosphate sachets significantly increases serum hemoglobin levels in non-pregnant women of reproductive age.
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Micronized, Microencapsulated Ferric Iron Supplementation in the Form of >Your< Iron Syrup Improves Hemoglobin and Ferritin Levels in Iron-Deficient Children: Double-Blind, Randomized Clinical Study of Efficacy and Safety; Jr Nutrients 2021
Key Findings
A 12-week supplementation with microencapsulated Iron Syrup resulted in a significant increase in ferritin and hemoglobin levels as compared to placebo (p = 0.04 and p = 0.02). Adverse events were reported with similar frequencies across both study arms. Ferric pyrophosphate microencapsulated represents an effective, well-tolerated, and safe option for the management of nutritional iron deficiency in children.
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https://www.mdpi.com/2072-6643/13/4/1087
Liposomal Iron for Iron Deficiency Anemia in Women of Reproductive Age: Review of Current Evidence; Jr of OB & Gynecology 2018
Key Findings
Encapsulation of micronized iron in liposomes is associated with lesser exposure to gastric contents, lesser interaction with food contents, no exposure to different digestive juices, targeted delivery of iron and allows lower doses to be administered in lieu of direct absorption without need for protein carriers. The available evidence suggests that liposomal iron significantly increases hemoglobin, ferritin levels in pregnant women as well as in women with iron deficiency.
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https://www.scirp.org/journal/paperinformation?paperid=87213
A Novel Approach for Iron Deficiency Anaemia with Liposomal Iron: Concept to Clinic; Jr of OB & G 2020
Key Findings
Conventional oral iron therapy is limited in many patients because of dose dependent side effects, insufficient absorption, lack of compliance and limitation in various inflammatory conditions. Liposomal iron is a technologically designed, innovative form of iron which due to its differential delivery system ensures higher absorption and bioavailability, greater tolerability and least gastro-intestinal side effects unlike conventional oral iron preparations. This review provides a critical discussion and a comprehensive view based on the author’s review of the medical literature concerning the technology of liposomal iron preparation, mechanism of its absorption, its advantage over conventional iron preparations and clinical evidence on its usage in iron deficient states in pregnancy and certain inflammatory conditions.
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https://www.scirp.org/journal/paperinformation?paperid=87213
Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: A randomised, double-blind, placebo-controlled study in Spanish iron-deficient women; Br Jr of Nutrition 2011
Key Findings
The fruit juice consumption involved increased intake of carbohydrates and vitamin C, and increased BMI within normal limits. Ferritin was higher in the F group after week 4 (P < 0·05) and became 80 % higher than in the P group after week 16 (P < 0·001), and transferrin decreased in the F group compared with the P group after week 4 (P < 0·001). RDW was higher at weeks 4 and 8 in the F group compared with the P group (P < 0·05). Transferrin saturation increased after week 8, and haematocrit, MCV and Hb increased after week 12, in the F group compared with the P group. Serum Fe did not change. sTfR and ZnPP decreased in the F group at week 16 (P < 0·05). Iron pyrophosphate-fortified fruit juice improves Fe status and may be used to prevent Fe-deficiency anaemia.
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Oral Liposomal Iron: A Treatment Proposal for Anemia; World Jr of Anemia 2017
Key Findings
The prevalence of any type of anemia is very high (>95%) among children, adolescents, and pregnant women in India. The main risk factors for iron deficiency anemia (IDA) are: Low iron intake, different levels of chronic blood loss, and malabsorption. In addition, certain chronic diseases like chronic kidney disease (CKD), chronic heart failure, cancer, and inflammatory bowel disease (IBD) are frequently associated with IDA.2,4 Iron deficiency anemia is also known to affect a large part of adult and elderly patients in internal medicine units. The distinctive features of liposomal iron like high bioavailability, lesser side effects, and good compliance make it suitable to be used in patients who require iron administration and are intolerant to oral treatment, IV iron treatment, or lack good absorption.
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https://www.wjoanemia.com/doi/WJOA/pdf/10.5005/jp-journals-10065-0019
Oral Ferric Pyrophosphate Formulation Utilization Surveillance Study to Assess Clinical Impact on Hemoglobin levels: Maxiim-Hemoglobin Study; Int jr of scientific study 2019
Key Findings
A total of 60 gynecologists participated and completed the survey, which involved 1073 pregnant subjects and patients suffering from IDA (864 patients, i.e., 80%). Mean Hb level at baseline was found to be 8.98 g/dl, 10.03 at week 4, and 10.99 at week 8. Thus, rise of Hb from baseline to week 8 was found to be 2.01 g/dl. Adverse events were reported in only 10 patients. The study suggests that oral Ferric pyrophosphate formulation therapy can serve as potent choice of therapy for IDA in pregnancy, both therapeutically and prophylactically.
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https://www.ijss-sn.com/uploads/2/0/1/5/20153321/10_ijss_jan_oa10_-_2019.pdf
Tarangani –
No gastritis, unlike other iron brands like ferium, c-pink and veg capsule makes it more suitable. Precifer i recommend
Dr.Rajagopal –
I am naturopathy practitioner and first time i am seeing encapsulated iron with lactoferrin addition, which i consider as the most logical way to boost low Hb count. Good results and no side effects; am happy with Precifer
sandeep arora –
Precifer -product and packing looks good and i hope it should be working to normalize my hemoglobin.
linda thomas –
i was using an imported ferric iron and it was expensive. Now i am getting same benefits with Precifer; happy to use and recommend.
Roja –
For my anemia related to pregnancy when the doctor prescribed some regular iron and it was causing severe gastritis. same time i came to know about Precifer thru a friend and my doctor also allowed to shift to precifer. Result is good, no gastritis and my hb level improved with 4 weeks.